Fri Sep 19 2025

118 articles - From Friday Sep 12 2025 to Friday Sep 19 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gut

British Society of Gastroenterology adult guidelines on inflammatory bowel disease: what can we learn for children and young people?

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Meta-analysis

meta-analyses and systematic reviews

Clin Gastroenterol Hepatol

Incidence of Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Reconstructed Individual Patient Data Meta-Analysis.

This reconstructed individual participant data meta-analysis provides updated estimates for HCC incidence in people with MASLD. The incidence of HCC is elevated in people with MASLD and advanced fibrosis. These data may have implications for further research in HCC surveillance and future development of surveillance algorithms.

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Performance of Fecal Immunochemical Test in Individuals with Personal history of Polyps and Family History of Colorectal Cancer: A Systematic Review.

Current evidence is limited to adequately assess diagnostic performance of FIT in individuals with family history of CRC, or as follow up after polypectomy.

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Endosc Int Open

Artificial Intelligence-Assisted Colonoscopy With or Without Mucosal Exposure Device for Detection of Colorectal Adenomas: A Meta-Analysis.

Endocuff combined with AI was superior to AI alone in improving the adenoma detection rate without increasing intubation or withdrawal times.

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Intragastric balloon for obesity treatment: Systematic review and meta-analysis of randomized controlled trials.

In obese adults, IGB is more effective than SMT for weight loss at 6, 9, and 12 months.

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Peroral cholangioscopy for detecting residual stones missed by cholangiography: Systematic review and meta-analysis.

POC identified residual stones in over one-fourth of patients following negative cholangiography. Detection rates were highest with digital systems. The procedure demonstrated a strong safety profile and may play an important role in confirming complete ductal clearance.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Clinical Trial: Evaluating a Single 1600 mg Tablet Regimen of 5-Aminosalicylate for Ulcerative Colitis-The EASI Trial.

The single-tablet lower dose treatment could be a feasible alternative to the conventional three-tablet regimen.

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IL23 Receptor Polymorphism Is a Predictor of Anti-Tumour Necrosis Factor-α-Induced Paradoxical Psoriasis in Inflammatory Bowel Disease.

Variation in the IL23R gene may identify those at risk of anti-TNFα-induced PP, beyond clinical variables. Further validation of this finding may promote its utility as a clinically actionable tool for the safe delivery of IBD medical therapy.

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Clin Gastroenterol Hepatol

Association between sustained virological response and adverse liver-related events in patients with decompensated HCV cirrhosis.

SVR was associated with a reduced risk of LREs in patients with decompensated HCV cirrhosis with a MELD score <15, whereas no clinical benefit was observed in those with higher MELD scores despite an SVR-associated MELD decrease.

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Effectiveness and Safety of Orodispersible Budesonide for Eosinophilic Esophagitis: A Multicenter Real-World Study.

Our real-world data confirm that BOTs are effective in inducing clinical and histologic remission in most EoE patients. The drug has a good safety profile, with side effects occurring only in a small number of patients.

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Impact of Extended Risankizumab Treatment in Patients With Ulcerative Colitis Who Did Not Respond to Induction Treatment.

Over 50% of initial nonresponders achieved clinical response with extended risankizumab treatment. Additional clinical and endoscopic outcomes were also achieved, with sustained or improved efficacy observed following maintenance. Extended treatment was well tolerated with no new safety risks identified; ClincialTrials.gov number, NCT03398148 (INSPIRE), NCT03398135 (COMMAND).

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Maintenance treatment for type 1 autoimmune pancreatitis: effectiveness and development of the PrescrAIP relapse prediction model.

Maintenance therapy reduced relapse only in patients at high relapse risk. Once externally validated, the PrescrAIP score may guide personalized maintenance treatment decisions.

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Morphometric quantification of steatosis and fibrosis in metabolic liver disease associated with type 2 diabetes.

Our study demonstrates the relevance of quantitative morphometric assessment of steatosis and fibrosis in T2DM patients with MASLD. Such an easily applicable approach could be used in routine practice to better characterize two cardinal features of the disease and to improve monitoring.

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Novel HBV biomarkers-guided NAs withdrawal strategy promotes HBsAg clearance in Asian CHB patients: a randomized controlled trial.

Asian patients with long-term HBV suppression benefit from NAs discontinuation guided by novel HBV markers, which provides rationale for finite NAs treatment.

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Prevalence of fibrosis and applicability of lab-based non-invasive tests from primary to tertiary care.

Prevalence of fibrosis in contemporary SLD patients was ∼7% in primary/secondary care, being especially pronounced in individuals with diabetes or obesity. LiverPRO and LiverRisk score optimize referral pathways.

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Real-world use of terlipressin in cirrhosis and acute kidney injury: frequent use beyond hepatorenal syndrome.

Terlipressin is often used for treatment of AKI outside its primary indication of HRS-AKI. Compared to patients with HRS-AKI, response to terlipressin is significantly lower in patients with ATN, in whom the risks may outweigh the benefits. Respiratory failure is common, but does not seem to be driven by the amount of albumin received nor ACLF grade.

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Supplementary Material for Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data from Nine Countries.

Work productivity losses are projected to more than double in most countries, and health-related quality of life will decline modestly as the burden of advanced disease increases CONCLUSIONS: Without intervention, the clinical, economic, and quality-of-life burden of MASH is projected to increase across most regions of the world. These findings highlight the urgent need for both national and global strategies to reduce the negative impact of MASH on individuals and society.

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The optimal cutoffs of liver stiffness measurement for staging fibrosis in on-treatment patients with chronic hepatitis B.

The optimal cutoffs for diagnosing ≥F2/F3 and F4 in on-treatment patients with CHB were 7.6 kPa and 9.0 kPa, these cut-offs could be reliably and repeatedly applied for long-term monitoring of patients with CHB under antiviral therapy.

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Upadacitinib is associated with better clinical and biochemical outcomes than tofacitinib in refractory, moderate-to-severe UC.

UPA might be associated with better short- and mid-term clinical and biochemical outcomes compared with TOFA in refractory, moderate-to-severe UC.

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Endosc Int Open

Assessing outcomes of full-thickness resection in piecemeal polypectomy scar consolidation of colon adenomas containing cancer.

EFTR could offer endoscopists a safe, efficacious, and minimally invasive mechanism for formal tumor (T) staging of malignancies found within polypectomy segments. Further studies with larger sample sizes are needed to assess outcomes in patients with residual neoplastic disease.

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Characterization of biomechanical risk factors during endoscopic submucosal dissection: Ergonomic pilot study.

ESD increased the risk of musculoskeletal strain. It is crucial to develop prevention programs to reduce risk of MSD in the population of gastroenterologists.

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Comparison of three electrosurgical modes for endoscopic mucosal resection of 10- to 20-mm colorectal polyps: Randomized controlled trial.

Endocut Q (effect 2, effect 3 and effect 4) was effective and safe for removing 10- to 20-mm non-pedunculated colorectal polyps. However, effect 2 may be superior to effect 3 and effect 4 in reducing intra-procedural bleeding.

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Fully-covered metal stent removal failure in case of non-malignant biliary strictures: Risk factors and resolution technique.

FC-SMES-in-FC-SEMS technique appears to be safe and effective to overcome FC-SEMS removal failure in patients with non-malignant distal biliary strictures. Reducing dwell stenting period, especially in patients with personal history of previous biliary stenting, may reduce risk of FC-SEMS removal failure.

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Influence of a defoaming agent - simethicone - on endoscope cleaning and disinfection: Prospective real-world study.

Simethicone may remain in the biopsy and water infusion channels, regardless of whether it is used or not. It is recommended to utilize a simethicone concentration of 1% or less when administering it through the biopsy or auxiliary water channels of the endoscope.

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Preventive wound drainage reduces esophageal fistula or infection after endoscopic resection of giant submucosal tumors in the esophagus.

In the context of STER for giant esophageal submucosal tumors with muscular layer full-thickness resection and mucosal injury, preventive drainage is an effective strategy for minimizing postoperative esophageal fistula and submucosal infection complications.

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Push enteroscopy and colonoscopy in melena patients with negative esophagogastroduodenoscopy: Prospective multicenter study.

PE is beneficial for patients with melena and nondiagnostic EGD. It should be considered before or in combination with colonoscopy for these patients.

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Transoral incisionless fundoplication for patients with gastroesophageal reflux disease after peroral endoscopic myotomy: Prospective cohort.

Use of TIF seems to be a feasible alternative for treating GERD after POEM, improving both clinical and endoscopic parameters and pHmetry in a considerable percentage of cases.

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Yield of next-generation sequencing in diagnostic work up of suspicious biliary strictures.

NGS in brushes contributed to more accurate/sensitive diagnoses of malignancy than morphology alone. There was a limited impact on CDM change, but in the future, NGS will undoubtedly play a bigger role when targeted therapy is incorporated in standard treatment and more sensitive NGS panels for cholangiocarcinoma are developed.

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Endoscopy

Performance measures for upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative - Update 2025.

Patients undergoing a diagnostic UGI endoscopy should have their experience measured using a validated scale, to promote a patient-centered and quality-driven environment. Patients with nondysplastic BE or gastric precancerous conditions in an endoscopic surveillance program should be monitored for guideline interval adherence.

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Prospective clinical validation of a novel artificial intelligence system for real-time detection of solid pancreatic masses during endoscopic ultrasonography.

Performance of AI-EUS was not significantly different to experienced endosonographers for detection and segmentation of solid pancreatic masses. By standardizing performance, AI-EUS may have potential to optimize clinical outcomes in pancreatic cancer.

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Gastrointest Endosc

A novel robotic arm-assisted endoscopic submucosal dissection platform with augmented traction for gastric neoplasms: a first-in-human prospective pilot study (with videos).

R-ESD proved feasible and safe in gastric ESD through high en bloc resection rates and dissection speed. R-ESD holds promise for improving procedural safety and performance through augmented traction.

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Cold Snare Polypectomy versus Hot Snare Polypectomy for Small Pedunculated Polyps: A Cost-Effectiveness Analysis.

CSP is cost-effective compared to HSP for small pedunculated polyps at a willingness-to-pay threshold of $100,000/QALY. Despite a higher IPPB risk, CSP's lower DPPB risk underlies its favorable economic profile. Our findings support CSP as the preferred technique for small pedunculated polyps, while emphasizing that patient- and polyp-specific clinical factors should be considered alongside cost-effectiveness in practice.

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Endosonography guided Coloenterostomy for Palliative Management of Peritoneal Carcinomatosis.

EUS-guided CE for palliative management of SBI caused by peritoneal carcinomatosis is feasible and safe. The intervention boasts a high clinical success rate with immediate symptom relief and significant improvement of symptom-compensated and overall survival.

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LONG-TERM FOLLOW-UP OF PATIENTS UNDERGOING CHOLANGIOPANCREATOSCOPY-GUIDED LASER DISSECTION AND ABLATION FOR REFRACTORY PANCREATIC AND BILIARY STRICTURES.

CPL has high technical success and an acceptable safety profile for the treatment of benign refractory BD and PD strictures.

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Long-term outcomes after endoscopic resection for cervical esophageal squamous cell carcinoma.

The long-term outcomes following ER for cervical ESCC in this study were comparable to those previously reported for thoracic ESCC in the literature.

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Outcomes of Submucosal Tunneling Endoscopic Resection for Subepithelial Tumors in the Upper Gastrointestinal Tract: Experience from the United States.

STER is a safe and effective approach for selected UGI SELs. Extraluminal extension, GIST histology, and SF predict the need for TMR. R1 resection was more common with TMR with increased procedural time. Minimizing pre-resection sampling may reduce fibrosis and optimize outcomes.

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Transmural Gallbladder Drainage Using a Novel Endosonographic-Guided Suture Device.

This study demonstrates the safety and effectiveness of a novel device which allowed for endoscopic anchoring of the gallbladder to the gastrointestinal lumen. This facilitated successful completion of EUS-GBD and may have implications for other interventional EUS procedures.

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Gut

<i>Holdemanella biformis</i> augments washed microbiota transplantation for the treatment of radiation enteritis.

This study overcomes the aforementioned recognised limitations with probiotics and microbiota transplantation and provides a new research paradigm in the concept of microbiome-based therapeutics.

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Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells.

These findings reveal a novel mechanism by which fructose fosters tumour progression through the modulation of tumour-stroma interactions, and highlight the therapeutic potential of targeting fructose metabolism in CRC to disrupt the tumour-stroma crosstalk that drives malignancy.

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Research priorities for cancers of the oesophagus and stomach: recommendations from a UK and Ireland patient and healthcare professional partnership exercise.

This work highlights the impact of patient input on HCP-ranked research priorities and provides a robust list of priorities to guide funders, policymakers and researchers to support and undertake impactful research.

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Hepatology

IL1β Signaling Mediates the Interaction Between Hepatitis B and C Viruses.

Our findings reveal a macrophage-derived, IFN-independent mechanism by which HCV suppresses HBV infection, mediated through IL1β. These insights highlight the complex crosstalk between hepatotropic viruses during coinfection and suggest that targeting IL1β-regulated pathways may offer therapeutic potential to prevent HBV reactivation in DAA-treated patients.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Managing the Moving Target-Dose Adjustments in Inflammatory Bowel Disease.

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Editorial: Ulcerative Colitis Management in the Biologic Era-Data From the English Healthcare Databases.

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Endosc Int Open

Endoscopic papillectomy of major papilla lesions: Single tertiary care center experience.

Pubmed   Journal   ReadQx   PMC

Gastroenterology

For early rectal neoplasms, the time has come to move beyond the TAMIS era: ESD is no longer the challenger - it is the standard to beat.

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How should endoscopists approach patients with upper gastrointestinal bleeding and persistent hemodynamic instability?

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New-Onset Diabetes: A Window into Early Pancreatic Cancer Detection?

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Gastrointest Endosc

SEDATION AND ANESTHESIA IN GI ENDOSCOPY IN 2025: HOW, WHO, AND WHY.

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J Hepatol

EASL Community Award Recipient 2025: Prof. Annalisa Berzigotti.

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EASL Recognition Award Recipient 2025: Prof. Jessica Zucman-Rossi.

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EASL Recognition Award Recipient 2025: Prof. Ulrich Beuers.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Letter to the Editor.

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Clin Gastroenterol Hepatol

Early ileocecal resection or tumor necrosis factor inhibitor in Crohn's disease: Replication in a Swedish cohort.

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Fecal Microbiota-based therapies compared to Fecal Microbiota Transplantation for Preventing recurrent C. difficile Infection.

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Inverted Hyperplastic Polyp Masquerading as a Gastric Subepithelial Tumor.

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Small Intestinal Stricture with Intense <sup>18</sup>F-FDG PET Activity Caused By Endometriosis.

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Endoscopy

A rare case of submucosal foreign body in the duodenal bulb.

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A rare extraction basket impaction: tracing back to biliary tract surgery 10 years ago.

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Delayed bleeding after peroral endoscopic myotomy for achalasia: conquered by clearing tunnel clots and identifying the bleeding site.

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Endoscopic retrieval of fragmented pancreatic stent in pediatric pancreas divisum using pancreatoscopy.

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Endoscopic submucosal dissection for early cancer using the water pressure method in the remnant rectum after Hartmann's procedure.

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Endoscopic subserosal dissection combined with the pocket-creation method for the treatment of exophytic gastric gastrointestinal stromal tumor.

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Endoscopic ultrasound-guided ablation of a metastatic hepatogastric lymph node from esophageal cancer using absolute ethanol.

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Endoscopic ultrasound-guided selective inflow vessel devascularization: a novel approach in treatment of large gastric varices.

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Feasibility of using a novel multibending accessory device designed for a slim therapeutic endoscope.

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Internal traction combined with underwater endoscopic submucosal dissection for a rectal neuroendocrine tumor.

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Non-thermal resection device for residual Barrett ablation in patient already treated by endoscopic submucosal dissection for initial esophageal neoplasia with high grade dysplasia.

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Pan-esophageal squamous papillomatosis with high grade dysplasia managed with endoscopic submucosal dissection.

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Reintervention using cholangioscopy for metallic stent obstruction following endoscopic ultrasound-guided hepaticogastrostomy.

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Rescue method using a covered metal stent with an ultra-slim delivery system for failed endoscopic ultrasound-guided rendezvous.

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Retrieval of a migrated biliary stent using a customized goose-neck snare.

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Salvage hemostasis with endoscopic suturing for refractory transverse colonic ulcer bleeding.

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Submucosal saline injection-assisted endoscopic ultrasonography for accurate layer identification of a rectal subepithelial lesion.

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Successful pancreatic duct cannulation using a novel rotatable dual-action sphincterotome at the pancreaticojejunostomy site.

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The "EndoBubbloMeter": a novel orientation method to facilitate straight tunneling in peroral endoscopic myotomy.

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Underwater traction-assisted endoscopic submucosal dissection of a neuroendocrine tumor in the duodenal bulb.

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Use of an augmented reality headset to optimize ergonomics in digestive endoscopy settings.

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Gastroenterology

A rare case of recurrent abdominal pain with facial edema.

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Fecal microbiota transplantation for primary Clostridioides difficile infection. Ready for prime time?

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GERD and its Complications Associated with GLP-1 Receptor Agonists.

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Gastroenterology Gastro Curbside Consult Submission.

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Magnitude and characteristics of NIDDK grant rescissions.

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Microbiota transplant - it's a match and a mismatch.

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The Enteric Nervous System Tastes Your Food!

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Gastrointest Endosc

Best of ESD,2025.

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Best of EUS-Guided Transluminal Interventions in 2025.

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Grafting to prevent esophageal strictures after endoscopic submucosal dissection (with video).

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Submucosal tunneling to extract a bullet from the mediastinum.

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Gut

Endoscopic Retrograde Cholangiopancreatography (ERCP) services across the UK.

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Endoscopic papillectomy: 'be prepared for unexpected'.

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Hepatology

A prognostic model in patients with alcohol-related cirrhosis does exist.

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Decoding the PSC fibrotic niche: Hepatocyte stress and metallothioneins.

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Letter to the Editor : Insights into Immune-Mediated adverse events and survival outcomes : Lessons from HIMALAYA.

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Letter to the Editor: Concerns regarding the diagnostic utility of non-invasive tests for clinically significant liver disease.

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Letter to the Editor: Diabetes and fibrosis: Parallel risks or overlap?

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Letter to the Editor: Screening and risk stratification disparities in hispanic MASLD.

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Letter to the editor: Technical considerations in the development of a multimodal deep learning model for predicting hepatocellular carcinoma outcomes.

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One step closer to a pan-genotypic hepatitis C vaccine.

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REPLY: Concerns regarding the diagnostic utility of non-invasive tests for clinically significant liver disease.

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Reply: "Screening and risk stratification disparities in hispanic MASLD".

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Reply: Diabetes and fibrosis: Parallel risks or overlap?

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Reply: Insights into immune-mediated adverse events and survival outcomes: Lessons from HIMALAYA.

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Reply: Technical considerations in the development of a multimodal deep learning model for predicting hepatocellular carcinoma outcomes.

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Reply: a prognostic model in patients with alcohol-related cirrhosis does exist.

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J Hepatol

From the Editor's Desk...

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Managing the Moving Target-Dose Adjustments in Inflammatory Bowel Disease. Authors' Reply.

Pubmed   Journal   ReadQx 

Letter on "Long-Term Dynamic Changes of Alanine Aminotransferase Levels Are Associated With Liver-Related Events in Nucleos(t)ide Analogue-Treated Chronic Hepatitis B Patients in China".

Pubmed   Journal   ReadQx 

Letter on 'Long-Term Dynamic Changes of Alanine Aminotransferase Levels Are Associated With Liver-Related Events in Nucleos(t)ide Analogue-Treated Chronic Hepatitis B Patients in China'-Authors' Reply.

Pubmed   Journal   ReadQx 

Letter: Drug-Induced Autoimmune-Like Hepatitis-A Trigger on the Disease Spectrum.

Pubmed   Journal   ReadQx 

Letter: Drug-Induced Autoimmune-Like Hepatitis-A Trigger on the Disease Spectrum. Authors' Reply.

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Clin Gastroenterol Hepatol

Considerations on TIPS Stent Diameter Selection in Patients with Cirrhosis at Risk of Hepatic Encephalopathy.

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Letter to the editor: The global rising tide of advanced fibrosis / cirrhosis.

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Novel tools for assessment of neurocognitive outcomes in infants born to women with inflammatory bowel disease.

Pubmed   Journal   ReadQx 

Response to Dell'Anna ('Rethinking EUS-choledochoduodenostomy with LAMS: the Indication Matters as Much as the Stent').

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Response to Letter Regarding "Efficacy of 6-mm and 8-mm TIPS for Variceal Bleeding".

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Gut

Disease-associated hepatocytes are predictive of outcomes and survival in MASLD beyond fibrosis staging.

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Gut microbiome comparability between DNA extraction kits.

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Sucrase-isomaltase hypomorphic variant Val15Phe affects the response to a sucrose challenge test in patients with IBS.

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