118 articles - From Friday Sep 12 2025 to Friday Sep 19 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gut |
|---|
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
|---|
Incidence of Hepatocellular Carcinoma in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Reconstructed Individual Patient Data Meta-Analysis. This reconstructed individual participant data meta-analysis provides updated estimates for HCC incidence in people with MASLD. The incidence of HCC is elevated in people with MASLD and advanced fibrosis. These data may have implications for further research in HCC surveillance and future development of surveillance algorithms. |
Performance of Fecal Immunochemical Test in Individuals with Personal history of Polyps and Family History of Colorectal Cancer: A Systematic Review. Current evidence is limited to adequately assess diagnostic performance of FIT in individuals with family history of CRC, or as follow up after polypectomy. |
| Endosc Int Open |
Artificial Intelligence-Assisted Colonoscopy With or Without Mucosal Exposure Device for Detection of Colorectal Adenomas: A Meta-Analysis. Endocuff combined with AI was superior to AI alone in improving the adenoma detection rate without increasing intubation or withdrawal times. |
Peroral cholangioscopy for detecting residual stones missed by cholangiography: Systematic review and meta-analysis. POC identified residual stones in over one-fourth of patients following negative cholangiography. Detection rates were highest with digital systems. The procedure demonstrated a strong safety profile and may play an important role in confirming complete ductal clearance. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
IL23 Receptor Polymorphism Is a Predictor of Anti-Tumour Necrosis Factor-α-Induced Paradoxical Psoriasis in Inflammatory Bowel Disease. Variation in the IL23R gene may identify those at risk of anti-TNFα-induced PP, beyond clinical variables. Further validation of this finding may promote its utility as a clinically actionable tool for the safe delivery of IBD medical therapy. |
| Clin Gastroenterol Hepatol |
Association between sustained virological response and adverse liver-related events in patients with decompensated HCV cirrhosis. SVR was associated with a reduced risk of LREs in patients with decompensated HCV cirrhosis with a MELD score <15, whereas no clinical benefit was observed in those with higher MELD scores despite an SVR-associated MELD decrease. |
Effectiveness and Safety of Orodispersible Budesonide for Eosinophilic Esophagitis: A Multicenter Real-World Study. Our real-world data confirm that BOTs are effective in inducing clinical and histologic remission in most EoE patients. The drug has a good safety profile, with side effects occurring only in a small number of patients. |
Impact of Extended Risankizumab Treatment in Patients With Ulcerative Colitis Who Did Not Respond to Induction Treatment. Over 50% of initial nonresponders achieved clinical response with extended risankizumab treatment. Additional clinical and endoscopic outcomes were also achieved, with sustained or improved efficacy observed following maintenance. Extended treatment was well tolerated with no new safety risks identified; ClincialTrials.gov number, NCT03398148 (INSPIRE), NCT03398135 (COMMAND). |
Maintenance treatment for type 1 autoimmune pancreatitis: effectiveness and development of the PrescrAIP relapse prediction model. Maintenance therapy reduced relapse only in patients at high relapse risk. Once externally validated, the PrescrAIP score may guide personalized maintenance treatment decisions. |
Morphometric quantification of steatosis and fibrosis in metabolic liver disease associated with type 2 diabetes. Our study demonstrates the relevance of quantitative morphometric assessment of steatosis and fibrosis in T2DM patients with MASLD. Such an easily applicable approach could be used in routine practice to better characterize two cardinal features of the disease and to improve monitoring. |
Novel HBV biomarkers-guided NAs withdrawal strategy promotes HBsAg clearance in Asian CHB patients: a randomized controlled trial. Asian patients with long-term HBV suppression benefit from NAs discontinuation guided by novel HBV markers, which provides rationale for finite NAs treatment. |
Prevalence of fibrosis and applicability of lab-based non-invasive tests from primary to tertiary care. Prevalence of fibrosis in contemporary SLD patients was ∼7% in primary/secondary care, being especially pronounced in individuals with diabetes or obesity. LiverPRO and LiverRisk score optimize referral pathways. |
Real-world use of terlipressin in cirrhosis and acute kidney injury: frequent use beyond hepatorenal syndrome. Terlipressin is often used for treatment of AKI outside its primary indication of HRS-AKI. Compared to patients with HRS-AKI, response to terlipressin is significantly lower in patients with ATN, in whom the risks may outweigh the benefits. Respiratory failure is common, but does not seem to be driven by the amount of albumin received nor ACLF grade. |
Supplementary Material for Projected Global Clinical, Humanistic, and Economic Impact of Metabolic Dysfunction-Associated Steatohepatitis (MASH): The Cost of Inaction Based on Data from Nine Countries. Work productivity losses are projected to more than double in most countries, and health-related quality of life will decline modestly as the burden of advanced disease increases CONCLUSIONS: Without intervention, the clinical, economic, and quality-of-life burden of MASH is projected to increase across most regions of the world. These findings highlight the urgent need for both national and global strategies to reduce the negative impact of MASH on individuals and society. |
The optimal cutoffs of liver stiffness measurement for staging fibrosis in on-treatment patients with chronic hepatitis B. The optimal cutoffs for diagnosing ≥F2/F3 and F4 in on-treatment patients with CHB were 7.6 kPa and 9.0 kPa, these cut-offs could be reliably and repeatedly applied for long-term monitoring of patients with CHB under antiviral therapy. |
| Endosc Int Open |
Assessing outcomes of full-thickness resection in piecemeal polypectomy scar consolidation of colon adenomas containing cancer. EFTR could offer endoscopists a safe, efficacious, and minimally invasive mechanism for formal tumor (T) staging of malignancies found within polypectomy segments. Further studies with larger sample sizes are needed to assess outcomes in patients with residual neoplastic disease. |
Comparison of three electrosurgical modes for endoscopic mucosal resection of 10- to 20-mm colorectal polyps: Randomized controlled trial. Endocut Q (effect 2, effect 3 and effect 4) was effective and safe for removing 10- to 20-mm non-pedunculated colorectal polyps. However, effect 2 may be superior to effect 3 and effect 4 in reducing intra-procedural bleeding. |
Fully-covered metal stent removal failure in case of non-malignant biliary strictures: Risk factors and resolution technique. FC-SMES-in-FC-SEMS technique appears to be safe and effective to overcome FC-SEMS removal failure in patients with non-malignant distal biliary strictures. Reducing dwell stenting period, especially in patients with personal history of previous biliary stenting, may reduce risk of FC-SEMS removal failure. |
Influence of a defoaming agent - simethicone - on endoscope cleaning and disinfection: Prospective real-world study. Simethicone may remain in the biopsy and water infusion channels, regardless of whether it is used or not. It is recommended to utilize a simethicone concentration of 1% or less when administering it through the biopsy or auxiliary water channels of the endoscope. |
Preventive wound drainage reduces esophageal fistula or infection after endoscopic resection of giant submucosal tumors in the esophagus. In the context of STER for giant esophageal submucosal tumors with muscular layer full-thickness resection and mucosal injury, preventive drainage is an effective strategy for minimizing postoperative esophageal fistula and submucosal infection complications. |
Push enteroscopy and colonoscopy in melena patients with negative esophagogastroduodenoscopy: Prospective multicenter study. PE is beneficial for patients with melena and nondiagnostic EGD. It should be considered before or in combination with colonoscopy for these patients. |
Transoral incisionless fundoplication for patients with gastroesophageal reflux disease after peroral endoscopic myotomy: Prospective cohort. Use of TIF seems to be a feasible alternative for treating GERD after POEM, improving both clinical and endoscopic parameters and pHmetry in a considerable percentage of cases. |
Yield of next-generation sequencing in diagnostic work up of suspicious biliary strictures. NGS in brushes contributed to more accurate/sensitive diagnoses of malignancy than morphology alone. There was a limited impact on CDM change, but in the future, NGS will undoubtedly play a bigger role when targeted therapy is incorporated in standard treatment and more sensitive NGS panels for cholangiocarcinoma are developed. |
| Endoscopy |
Performance measures for upper gastrointestinal endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative - Update 2025. Patients undergoing a diagnostic UGI endoscopy should have their experience measured using a validated scale, to promote a patient-centered and quality-driven environment. Patients with nondysplastic BE or gastric precancerous conditions in an endoscopic surveillance program should be monitored for guideline interval adherence. |
Prospective clinical validation of a novel artificial intelligence system for real-time detection of solid pancreatic masses during endoscopic ultrasonography. Performance of AI-EUS was not significantly different to experienced endosonographers for detection and segmentation of solid pancreatic masses. By standardizing performance, AI-EUS may have potential to optimize clinical outcomes in pancreatic cancer. |
| Gastrointest Endosc |
A novel robotic arm-assisted endoscopic submucosal dissection platform with augmented traction for gastric neoplasms: a first-in-human prospective pilot study (with videos). R-ESD proved feasible and safe in gastric ESD through high en bloc resection rates and dissection speed. R-ESD holds promise for improving procedural safety and performance through augmented traction. |
Cold Snare Polypectomy versus Hot Snare Polypectomy for Small Pedunculated Polyps: A Cost-Effectiveness Analysis. CSP is cost-effective compared to HSP for small pedunculated polyps at a willingness-to-pay threshold of $100,000/QALY. Despite a higher IPPB risk, CSP's lower DPPB risk underlies its favorable economic profile. Our findings support CSP as the preferred technique for small pedunculated polyps, while emphasizing that patient- and polyp-specific clinical factors should be considered alongside cost-effectiveness in practice. |
Endosonography guided Coloenterostomy for Palliative Management of Peritoneal Carcinomatosis. EUS-guided CE for palliative management of SBI caused by peritoneal carcinomatosis is feasible and safe. The intervention boasts a high clinical success rate with immediate symptom relief and significant improvement of symptom-compensated and overall survival. |
LONG-TERM FOLLOW-UP OF PATIENTS UNDERGOING CHOLANGIOPANCREATOSCOPY-GUIDED LASER DISSECTION AND ABLATION FOR REFRACTORY PANCREATIC AND BILIARY STRICTURES. CPL has high technical success and an acceptable safety profile for the treatment of benign refractory BD and PD strictures. |
Outcomes of Submucosal Tunneling Endoscopic Resection for Subepithelial Tumors in the Upper Gastrointestinal Tract: Experience from the United States. STER is a safe and effective approach for selected UGI SELs. Extraluminal extension, GIST histology, and SF predict the need for TMR. R1 resection was more common with TMR with increased procedural time. Minimizing pre-resection sampling may reduce fibrosis and optimize outcomes. |
Transmural Gallbladder Drainage Using a Novel Endosonographic-Guided Suture Device. This study demonstrates the safety and effectiveness of a novel device which allowed for endoscopic anchoring of the gallbladder to the gastrointestinal lumen. This facilitated successful completion of EUS-GBD and may have implications for other interventional EUS procedures. |
| Gut |
<i>Holdemanella biformis</i> augments washed microbiota transplantation for the treatment of radiation enteritis. This study overcomes the aforementioned recognised limitations with probiotics and microbiota transplantation and provides a new research paradigm in the concept of microbiome-based therapeutics. |
Fructose drives colorectal cancer progression by regulating crosstalk between cancer-associated fibroblasts and tumour cells. These findings reveal a novel mechanism by which fructose fosters tumour progression through the modulation of tumour-stroma interactions, and highlight the therapeutic potential of targeting fructose metabolism in CRC to disrupt the tumour-stroma crosstalk that drives malignancy. |
Research priorities for cancers of the oesophagus and stomach: recommendations from a UK and Ireland patient and healthcare professional partnership exercise. This work highlights the impact of patient input on HCP-ranked research priorities and provides a robust list of priorities to guide funders, policymakers and researchers to support and undertake impactful research. |
| Hepatology |
IL1β Signaling Mediates the Interaction Between Hepatitis B and C Viruses. Our findings reveal a macrophage-derived, IFN-independent mechanism by which HCV suppresses HBV infection, mediated through IL1β. These insights highlight the complex crosstalk between hepatotropic viruses during coinfection and suggest that targeting IL1β-regulated pathways may offer therapeutic potential to prevent HBV reactivation in DAA-treated patients. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Endosc Int Open |
| Gastroenterology |
| Gastrointest Endosc |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Gut |